iModMix

Metabolomics abundance matrix

Principal component analysis for each phenotype

Select the phenotype of interest

Principal component analysis

Metabolomics annotation data

Sparse partial correlations: Metabolites

Partial correlation matrix

Hierarchical clustering

Hierarchical clustering Image (.png)

Cluster assignments

Cluster assigment table

First principal component from each module (Eigenfeatures)

Eigenfeatures table

Eigenfeatures heatmap

Eigenfeatures heatmap Image (.png)

Metadata

Note: Upload the metadata data to be able to run phenotype analysis.

Classification between phenotypes by eigenfeatures

Select the phenotype of interest

Select p-value Threshold

Classification table

Boxplot classification Image (.png)

Module screening

Select the module of interest

Module Features

PCA loading by module

PCA_Loadings

Heatmap by module

Heatmap

Proteomics/Genomics expression matrix

Principal component analysis for each phenotype

Select the phenotype of interest

Principal component analysis

Proteomics/Genomics annotation data

Sparse partial correlations: Proteins/Genes

Partial correlation

Hierarchical clustering

Hierarchical clustering Image (.png)

Cluster assignments

Cluster assigment

Cluster assignments enriched

Note: Upload the Annotation data to be able to run enrichment analysis.

Select Library

Enrichment analysis

First principal component from each module (Eigenfeatures)

Eigenfeatures table

Eigenfeatures heatmap

Eigenfeatures heatmap Image (.png)

Metadata

Classification between phenotypes by eigenfeatures

Select the phenotype of interest

Select p-value Threshold

Classification table

Boxplot classification Image (.png)

Module screening

Select the module of interest

Module Features

PCA loading by module

PCA_Loadings

Heatmap by module

Heatmap

Modules correlation
Important features

Correlation: Metabolites and Proteins/Genes

Select Correlation Threshold

Omics correlation

Module Network of Metabolites and Proteins/Genes

Network as .html

Top Multi-omics modules correlations

Select the number of top modules to visualize

Top module correlation details

Select Lists to Visualize

List of Metabolites

List of Proteins/Genes

Corrplot: Metabolites and Proteins/Genes

Modules correlation: Metabolites and Proteins/Genes

Modules correlation

Metabolites from top module

Metabolites_TopModule

Classification between phenotypes by Metabolites

Select the phenotype of interest

Select p-value Threshold

Proteins/Genes from top module

Proteins_Genes_TopModule

Classification between phenotypes by Proteins/Genes

Select the phenotype of interest

Select p-value Threshold

Upload Metabolomics Abundance Data

Upload Metabolomics Annotation Data

Upload Proteomics/Genomics Expression Data

Upload Proteomics/Genomics Annotation data

Upload Metadata

Metabolomics abundance matrix

Principal component analysis for each phenotype

Metabolomics annotation data

Sparse partial correlations: Metabolites

Hierarchical clustering

Cluster assignments

First principal component from each module (Eigenfeatures)

Eigenfeatures heatmap

Metadata

Classification between phenotypes by eigenfeatures

Module screening

PCA loading by module

Heatmap by module

Proteomics/Genomics expression matrix

Principal component analysis for each phenotype

Proteomics/Genomics annotation data

Sparse partial correlations: Proteins/Genes

Hierarchical clustering

Cluster assignments

Cluster assignments enriched

First principal component from each module (Eigenfeatures)

Eigenfeatures heatmap

Metadata

Classification between phenotypes by eigenfeatures

Module screening

PCA loading by module

Heatmap by module

Correlation: Metabolites and Proteins/Genes

Module Network of Metabolites and Proteins/Genes

Top Multi-omics modules correlations

Top module correlation details

List of Metabolites

List of Proteins/Genes

Corrplot: Metabolites and Proteins/Genes

Modules correlation: Metabolites and Proteins/Genes

Metabolites from top module

Classification between phenotypes by Metabolites

Proteins/Genes from top module

Classification between phenotypes by Proteins/Genes